CHEMISTRY

CHEMISTRY

Our fully-owned daughter company Philochem has developed a technology platform in the emerging field of DNA-encoded medicinal chemistry that allows us to generate large collections (or “libraries”) of chemical compounds of unprecedented size and functionality.

The DNA-encoded chemical library technology opens new possibilities for the development of novel conventional drugs and enables the generation of small molecule targeting agents with antibody-like properties in a more cost-effective way.

Philochem owns proprietary technologies and large DNA-encoded chemical libraries containing more than one billion compounds. These libraries are being used both for in-house discovery activities and for partnered programs.

Link to Philochem Website

SELECTED REFERENCES

Sannino et al. (2020) ACS Comb Sci, 22, 204-12
Gironda et al. (2019) Org Lett, 21, 9555-58
Li et al. (2018) Nat Chem, 10, 441–48
Neri and Lerner (2018) Annu Rev Biochem, 87, 479-502
Favalli et al. (2018) ChemMedChem, 13, 1303–7
Zimmermann et al. (2017) Chemistry, 34, 8152–5
Bigatti et al. (2017) ChemMedChem, 12, 1748–52
Zimmermann and Neri (2016) Drug Discov Today, 21, 1828-34
Wichert et al. (2015) Nat Chem, 7, 241-9
Franzini et al. (2015) Angew Chem Int Ed, 54 3927-31
Samain et al. (2015) J Med Chem, 58, 5143-49
Franzini et al. (2014) Bioconj Chem, 25, 1453-61
Leimbacher et al. (2012) Chem Eur, 18, 7729–37
Mannocci et al. (2010) Bioconj Chem, 21, 1836-41
Dumelin et al. (2008) Angew Chem Int Ed, 47, 3196-201
Scheuermann et al. (2008) Bioconj Chem, 19, 778-85
Mannocci et al. (2008) Proc Natl Acad Sci, 105, 17670-5
Melkko et al. (2007) Angew Chem Int Ed, 46, 4671-74
Melkko et al. (2004) Nat Biotechnol, 22, 568-74

This website or its third party tools use cookies, which are necessary to its functioning and required to achieve the purposes illustrated in the cookie policy. If you want to know more or withdraw your consent to all of the cookies, please refer to the cookie policy. By closing this banner, scrolling this page, clicking a link or continuing to browse otherwise, you agree to the use of cookies.

I Accept Cookie Policy
X