Onco IX (PHC-102)

Onco IX (PHC-102)

Onco IX (PHC-102) is a 99mTc labelled small molecule radiotracer for the non-invasive detection of carbonic anhydrase IX (CAIX) expressing solid tumors. The product consists of (i) a CAIX ligand derived from acetazolamide, (ii) a non-cleavable spacer and (iii) a peptide 99mTC chelator.

CAIX is a validated target, which is expressed in the majority of Renal Cell Carcinoma (RCC) patients, but also in a proportion of patients with other malignancies (e.g., ~30% of patients with Colorectal Carcinoma).

In preclinical studies, PHC-102 demonstrated high tumor uptake and excellent tumor-to-kidney ratios (i.e., 3:1 already 6 hours after intravenous administration).

The favorable tumor uptake and biodistribution of Onco IX has been validated by the successful imaging of primary and secondary RCC tumors in human patients.


  • A phase I study for the clinical development of Onco IX (PHC-102) as imaging agent in patients with RCC.


Kulterer et al. (2020) J Nucl Med, Online ahead of print
Cazzamalli et al. (2018) Clin Cancer Res, 24, 3656-67
Cazzamalli et al. (2018) J Am Chem Soc, 140, 1617-21
Cazzamalli et al. (2017) J Control Release, 246, 39-45
Cazzamalli et al., (2016) Mol Cancer Ther, 15, 2926-35
Krall et al. (2016) J. Nucl Med, 57, 943-9
Wichert et al. (2015) Nat Chem, 7, 241-9
Krall et al. (2014) Chem Sci, 5, 3640-4
Krall et al. (2014) Angew Chem Int Ed, 53, 4231-35


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