Fibromun (L19-TNF) is a fully-human immunostimulatory product, currently being tested in clinical trials in patients with cancer. It consists of the anti-EDB human antibody L19, fused to human TNF, a strong pro-inflammatory cytokine. Recombinant TNF (Beromun TM, Boehringer Ingelheim) has so far been approved only for certain clinical applications.
Fibromun has previously been studied in clinical trials in melanoma in the isolated limb-perfusion setting and in a systemic clinical trial.


  • a pivotal clinical trial for Fibromun in combination with doxorubicin in metastatic Soft Tissue Sarcoma is started in Europe and is about to start in the USA.
  • application to start a Phase I clinical trial in glioblastoma multiforme has been filed.


Hemmerle and Neri (2013) Br. J. Cancer 109 (5) 1206-13;
Papadia et al. (2013) J Surg Oncol., 107, 173-179;
Spitaleri et al (2013) J Cancer Res. Clin. Onc., 139, 447-455;
Balza et al. (2010) Int. J. Cancer, 127 (1) 101-10;
Balza et al. (2006) Clin. Cancer Res., 12, 2575-2582;
Borsi et al. (2003) Blood, 102, 4384-4392;
Halin et al (2003) Cancer Res., 63 (12) 3202-10.

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